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The most powerful card by a frustratingly large margin is most assuredly Thoughtseize

If you exiled a nonland card this way, create a Treasure token. More creatures is good, and Treasure tokens are famously absurd, so this seems like a great card in Lost Caverns of Ixalan

Flicker effects are one of the most efficient ways to trigger Ketramose, which makes it a natural inclusion in any Orzhov+ (+) blink shell

Voltron damage is also supported by Kellan, the Fae-Blooded and Bruenor Battlehammer, who enable hard-hitting turns with double strike and power boosts

The drawback is severe, but the payoff is worth it against the decks that are forcing your hand