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Frequency: one subcutaneous injection each day at a consistent time, titrating up as tolerated over a 12-week cycle

If reduced weight loss occurs despite continued use, increasing the dose is not advised

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Retatrutide is an investigational triple agonist (GLP-1, GIP, and glucagon receptors) still undergoing phase III trials, whilst sermorelin is an unlicensed growth hormone-releasing hormone analogue

Immediately discontinue use if allergic skin irritation or reaction occurs