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An exploratory mediation analysis of stroke outcomes in the REWIND CVOT, in which dulaglutide reduced systolic blood pressure (SBP) by a mean of 1.7 mmHg compared to placebo, found that the blood pressure reduction caused by dulaglutide accounts for around 14% of its effect on stroke risk [21]

Pivoting back to the obesity space, a year-long Phase 2 study comparing semaglutide daily to 0.6 mg of liraglutide daily and placebo demonstrated the superiority of semaglutide over liraglutide in all doses above 0.2 mg (NCT02453711)

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