Eg5 Inhibitor III - CAS# 863774-58-7 Catalog No.:M6537-2 1007/978-981-10-3233-2_15

1007/978-981-10-3233-2_15

with IC50 of 86 ± 10 μM and 181 ± 7 μM

5 nM and 303

Formula: C18H28ClN3O3

Molecular Weight: 250

Eg5 Inhibitor III - CAS# 863774-58-7 Catalog No.:M6537-2 1007/978-981-10-3233-2_15Eg5 Inhibitor III, CAS No. 863774 58 7, is an inhibitor of mitotic motor kinesin Eg5 (IC50 = 200 nM). Eg5 Inhibitor III suppresses human pancreatic cancer cell migration and invasion in vitro via allosteric inhibition of mitotic kinesin Eg5. The inhibition of kinesin Eg5 by small molecules such as monastrol is currently evaluated as an approach to develop a novel class of antiproliferative drugs for the treatment of malignant tumours. Product