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This strategy is currently restricted to three disulfide bonds and the synthesis of targets with more than three disulfide bonds will require the development of additional chemistry for chemoselective and regioselective disulfide bond formation

Indeed, a large number of previous studies examining the status of antioxidants in mucosa from patients and experimental animal models of colitis have reported a decrease in the levels of antioxidants, including that of GSH (Buffinton and Doe, 1995

doi: 10.3389/fphar.2024.1430561 Received 10 May 2024 Accepted 26 July 2024 Published 13 August 2024 Volume 15 - 2024 Edited by Michael Heinrich, University College London, United Kingdom Reviewed by Feng Zhang, Nanjing University of Chinese Medicine, China Hongquan Wang, Peking University Aerospace School of Clinical Medicine, China Updates Copyright 2024 Tian, Fu, Huang, Zou, Shi, Li, Bao, He and Lv