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Ethanol, especially spirits, in high amounts can damage the mucosal layer of the gastrointestinal tract

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Treatment of HCC cells with ADI-PEG20 downregulates the key enzymes of pyrimidine synthesis in the TCA cycle, carbamoyl phosphate synthetase 2, thymine synthase (TS), aspartate transcarbamylase and dihydrooratase (CAD) and malate dehydrogenase 1 (MDH-1) activities, making tumor cells more susceptible to 5-fluorouracil (5-FU)

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For long-term storage, store in a freezer at 20 C, where stability may be maintained for several months to years