SAR405838 atel 3-dimethyl-1-oxobutan-2-yl]carbamoyl}-3

3-dimethyl-1-oxobutan-2-yl]carbamoyl}-3

is a n orally bioavailable small molecule with potential antiangiogenic and antineoplastic activities

HDAC inhibitor 4SC-202 selectively binds to and inhibits class I HDACs leading to an accumulation of highly acetylated histones

pii: S1875-4597(16)30071-6

Jan Anderl

SAR405838 atel 3-dimethyl-1-oxobutan-2-yl]carbamoyl}-3SAR405838 is a highly potent and selective MDM2 inhibitor, binds to MDM2 with Ki= 0. 88 nM and has high specificity over other proteins. IC50 value: 0. 88 nM (Ki) [1] Target: MDM2 in vitro: SAR405838 potently inhibits cell growth in cancer cell lines, including SJSA 1 (IC50, 0. 092 M), RS4; 11 (IC50, 0. 089 M), LNCaP (IC50, 0. 27 M), and HCT 116 (IC50, 0. 20 M) cells, and displays high selectivity over cancer cell lines with mutated or deleted p53,