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Infection with the influenza virus was shown to decrease Claudin-5, a tight junction protein, in vitro 32 , while that protein has also been reported to be decreased in fetal lung sections infected with COVID-19 33

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Involvement of nicotinic acetylcholine receptors in suppression of antimicrobial activity and cytokine responses of alveolar macrophages to Legionella pneumophila infection by nicotine