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Given that mitochondrial dysfunction is an important factor for ferroptosis (146), Parkins role in mitophagy suggests a potential link

Its expression is induced by arsenite (AsIII), amino acid depletion, and the pollutant perfluorooctane sulfonate ( During arsenite stress, CHAC1 promotes apoptosis in HaCaT cells by degrading GSH and increasing oxidative stress sensitivity ( III , with CHAC1 knockdown reducing sensitivity to H 2 O 2