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Lustig RH, Mobbs CV, Bradlow HL, McEwen BS, Pfaff DW: Differential effects of estradiol and 16-hydroxyestrone on pituitary and preoptic estrogen receptor regulation

This article examines the science, potential risks, and NHS guidance surrounding this off-label approach

Doi: 10.1111/dom.16042 [DOI] [PMC free article] [PubMed] [Google Scholar] 152

Freezing damages the peptide molecules irreversibly by forming ice crystals that rupture cell membranes and break chemical bonds

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