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Paul, MN, USA) proprietary Biosystem XA software (version 2.9.0.2) and proprietary FinePointe software (version v2.8.0), as described previously 87,88,89,90,91,92,93,94,95,96,97 and as detailed in the Data Sciences International/Buxco website reference to the list of parameters provided by FinePointe Software using whole body plethysmography ( The BioSystem XA software extracts the waveforms that are analyzed by the FinePointe software that uses National Instruments Measurement Studio to perform these analyses ( Righting reflex Separate groups of adult male SpragueDawley rats were used to evaluate the effects of GSHee (100 mol/kg, IV) on the duration of fentanyl (75 g/kg, IV)-induced impairment of the righting reflex (inability to stand on all four legs)

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Mechanisms (Preclinical Only) Rodent and in vitro studies report modulation of the nitric oxide system via SrcCaveolin1eNOS signaling and context dependent effects on vascular tone

3 However, SUSTAIN 3 and other studies within the SUSTAIN series also reported significant weight loss as a benefit of semaglutide in addition to its blood sugar control properties