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Contraindications Saxenda is contraindicated in the following conditions: Personal or family history of medullary thyroid carcinoma (MTC) or Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) Patients with a prior serious hypersensitivity reaction to liraglutide or to any of the product components Pregnancy Warnings and Precautions Risk of Thyroid C-cell Tumors: If serum calcitonin is measured and found to be elevated, the patient should be further evaluated

Evaluation of IP3 production by measurement of IP1 accumulation using homogeneous time-resolved FRET (HTRF) Intracellular IP1 levels were measured using IP-One assay (Cisbio Bioassays, Codolet, France)

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