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Knockdown of DR4 abolishes NF-κB activation
This agent is less cardiotoxic than doxorubicin and exhibits activity against some doxorubicin-resistant cell lines
PubMed PMID: 31779982
Formula: C33H37N3O13
Sirt2-PROTAC-1 is a SirReal based PROTAC
AES-350 - CAS# 847249-57-4 12841 Knockdown of DR4 abolishes NF-κBAES 350 is a potent and orally active HDAC6 inhibitor with an IC50 and a Ki of 0. 0244 M and 0. 035 M, respectively. AES 350 is also against HDAC 3, 8, and 11 in an enzymatic activity assay with IC50 values of 0. 187 M, 0. 245 M, and >1M, respectively. AES 350 triggers apoptosis in AML cells through HDAC inhibition and can be used for acute myeloid leukemia (AML) research. Product information CAS Number: 847249 57 4 Molecular Weight: 312. 36 Formula:
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