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SUSTAIN-6 documented significant reduction in major adverse cardiovascular events in type 2 diabetes patients with established cardiovascular disease, and SELECT documented cardiovascular event reduction in obese patients without diabetes

Patients with renal or hepatic impairment, diabetic history, or concurrent medications require special dosing consideration

7 A number of NMDA antagonists have been reported to rapidly reversewithin a few hourssevere and chronic depression when administered intravenously (ketamine, rapastinel, scopolamine), intranasally (S-ketamine), or via inhalation (nitrous oxide)

Qi J, Huang W, Lu Y, Yang X, Zhou Y, Chen T, Wang X, Yu Y, Sun JQ, Chai R

Eur J Endocrinol, 2002, Vol 146 (6), pp 8639.