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Byetta (a twice daily dosed GLP-1), which is patent and regulatory exclusivity free, has multiple manufactures filing for generic approval, but there has been no movement on FDA approval yet

The safety of arginine was demonstrated even at the highest dosage of 8 grams, as reported by Neuzillet et al

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Compared with controls, the researchers observed: Fewer beneficial gut bacteria involved in breaking down dietary fiber Lower levels of short-chain fatty acids, compounds that help support the gut lining and play a role in inflammation control Higher levels of inflammatory markers in the blood Increased liver weight, which can be consistent with low-grade inflammation A smaller cecum the part of the intestine where gut bacteria break down fiber and produce protective compounds Reduced levels of a brain-derived protein associated with cognitive impairment Taken together, the results suggest SNAC may influence the gut ecosystem and inflammation-related pathways, not just medication absorption