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Weight loss with GLP-1 therapy is typically gradual rather than dramatic, and glycaemic improvements may take several weeks to become apparent

A reasonable combination of different treatments may have a significant synergy, especially for patients with intractable diseases or intolerance to monotherapy [8]

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A double blinded placebo controlled study using daily Orfoglipron (45 mg) in obese patients, found an average of 12.4% decrease in body weight over placebo after 36 weeks