Furthermore, accumulating evidence underscores the involvement of the gut microbiome in the aetiology of NAFLD through the mediation of NAFLD metabolites, such as trimethylamine N-oxide (TMAO) (Reference Chen and Vitetta7) , which is naturally found in seafood, dairy products, egg yolks, muscle and organ meats in a preformed state and is also a metabolite originating from precursors, including phosphatidylcholine, choline, betaine and l-carnitine (Reference Thomas and Fernandez8,Reference Li, Lu and Yuan9)
Variants in FTO (fat-mass and obesity-associated), GLP1R (the GLP-1 receptor gene and target of semaglutide), MC4R (a melanocortin receptor central to satiety and energy balance), and TCF7L2 (linked to glucose homeostasis) describe that terrain
2019, doi: 10.1001/jamacardio.2019.3780
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Int J Pept Res Ther 2022