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Although pentavalent methylated arsenicals (MAs V , DMAs V , TMAs V ) are less toxic than inorganic ones (iAs V , iAs III ), the trivalent intermediated formed during the methylation process (MAs III , DMAs III ) are much more cytotoxic and genotoxic (Hughes, 2009)

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Compounding these risks is the fact that long-term effects remain largely unknown, as millions of people are still in the early stages of taking these medications

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