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Tachyphylaxis where drugs become less effective over timecreates another key difference

Frohman, Lawrence A

Spermatogonial stem cell (SSC) transplantation and testicular tissue grafting are promising experimental therapies aiming to restore spermatogenesis

In silico approaches for designing highly effective cell penetrating peptides

As mentioned earlier, they bioactivate AFB 1 to an electrophilic, highly reactive and unstable metabolite known as aflatoxin-8,9-epoxide, which binds to guanine residues in nucleic acids, leading to irreversible damage in DNA and causing hepatocarcinoma in humans, primates, and ducks [32], [84]