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Thus, folate builds up in the form of 5mTHF (the "methyl trap") and there is less folate in the forms CH 2 -THF and 10f-THF that are the substrates for thymidylate and purine synthesis, respectively

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The modulation of these histone marks by IF-induced autophagy represents a key mechanism by which fasting influences the epigenome, potentially contributing to its beneficial effects on health span and longevity across generations [89, 91]

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