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Originally developed for type 2 diabetes, this class is now a cornerstone of medical weight loss

Electronic cigarette exposure and liver disease Electronic nicotine delivery systems (ENDS), commonly known as e-cigarettes or vaping devices, have gained widespread popularity, particularly among adolescents and young adults, due to the perception that they are safer than conventional cigarettes [117]

Inducible nitric oxide synthase (iNOS) and nitric oxide (NO) are important mediators of reflux-induced cell signalling in esophageal cells

At the same time, reduced IDO activity reduced kynurenine and further weakened peripheral immune tolerance, which played a driving role in the hypothyroidism immune disorder caused by the imbalance of the whole gut microbiota (Clarke et al., 2017)

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