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ROS generation leads to oxidation of the ASK1 inhibitor thioredoxin, separating and activating ASK1 from the inactive ASK1thioredoxin complex

The antibodies used included mouse anti-Cathepsin B antibody (Santa Cruz Biotechnology, sc-365558) 1:1000

Antiox Redox Signal 10:19411988 Minich T, Riemer J, Schulz JB, Wielinga P, Wijnholds J, Dringen R (2006) The multidrug resistance protein 1 (Mrp1), but not Mrp5, mediates export of glutathione and glutathione disulfide from brain astrocytes

Moreover, no defined clinical criteria for ME/CFS makes it even more complicated to compare various study results (586)